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Original Article
Correlation between Chest Radiographic Findings and Respiratory Indices in Neonates with Respiratory Distress Syndrome
Yong-Hwan Chung, Youn-Jin Park, Chong-Woo Bae, Dong-Wook Sung
Clin Exp Pediatr. 2003;46(7):655-660.   Published online July 15, 2003
Purpose : The relationship between chest X-ray findings and respiratory indices, including the arterial-alveolar oxygen partial pressure ratio(a/APO2) and the ventilatory index(VI), indicators of the clinical respiratory status in neonates with respiratory distress syndrome(RDS), was examined in the present study. Methods : The records of 50 neonates, randomly chosen from 174 neonates treated with pulmonary surfactant(PS) in the Neonatal Intensive Care...
A Clinical Study of the Acute Respiratory Distress Syndrome in Children
Taek Jin, Dong Soo Kim, Dong Hwan Shin
Clin Exp Pediatr. 2003;46(1):42-50.   Published online January 15, 2003
Purpose : The acute respiratory distress syndrome(ARDS), an acute form of severe alveolar-capillary injury evolving after a direct or indirect lung insult is thought to be a common cause of respiratory failure though not many clinical studies on the subject have been made yet. Methods : Between January 1992 and December 2001, we conducted a retrospective study on 33 children who...
Effect of Nasal Continuous Positive Airway Pressure after Early Surfactant Therapy in Moderate Respiratory Distress Syndrome
Eun Ji Kim, Hae Sook Kim, Man Hoe Hur, Sang Geel Lee
Clin Exp Pediatr. 2002;45(10):1204-1212.   Published online October 15, 2002
Purpose : Early surfactant therapy with either gentle ventilation, high-frequency ventilation or aggressive weaning of mechanical ventilation are principles for the treatment of respiratory distress syndrome(RDS). We studied to determine the accessibility of noninvasive nasal continuous positive airway pressure(CPAP) rather than mechanical ventilation by invasive intubation after early surfactant therapy. Methods : The study group consisted of 14 infants who were born and diagnosed with...
Thymus Size and Its Relationship to Perinatal Diseases; Respiratory Distress Syndrome and Intrauterine Growth Retardation
Sun Mi Chung, Woo Taek Kim
Clin Exp Pediatr. 2002;45(7):855-861.   Published online July 15, 2002
Purpose : Thymus size can be affected by several factors and perinatal diseases can be estimated by its size. The purpose of this study was to search for a relationship between cardiothymic/ thoracic(CT/T) ratio and perinatal diseases such as neonatal respiratory distress syndrome(RDS) and intrauterine growth retardation(IUGR) by measuring the width of the cardiothymic shadow at the level of the...
Case Report
A Case of Congenital Nasal Pyriform Aperture Stenosis
Hyoung Sik Oh, Sang Hee Kim, Gil Hyun Kim, Hak Soo Lee, Il Hwan Jang, Ji Hae Kim
Clin Exp Pediatr. 2001;44(1):99-102.   Published online January 15, 2001
The cause of congenital nasal pyriform aperture stenosis is unclear. The development of the facial skeleton occurs between the fifth and the eighth week of gestation. It is at this stage that the stenosis occurs due to overgrowth of the ossification of the maxilla. Infants are obligate nasal breathers. Incomplete and milder forms of nasal airway obstruction may be present...
Original Article
Short-term Effects of Inhaled Corticosteroid Following Early Systemic Corticosteroid Administration in Premature Babies with Respiratory Distress Syndrome : A Preliminary Report
Hyeon-Soo Lee
Clin Exp Pediatr. 2000;43(11):1440-1445.   Published online November 15, 2000
Purpose : To asses the short-term effects of the topical corticosteroid, budesonide administered by metered dose inhaler(MDI) and spacer(Aerochamber MV 15) following systemic corticosteroid in premature babies with respiratory distress syndrome at birth. Methods : 19 premature babies <1800gm were randomly assigned to receive steroids(n=9) or not (n=10). The steroid group(n=9, GA[gestational age]=29.6¡¾2.9 weeks, BW[birth weight]=1.29¡¾0.35kg) received systemic dexamethasone for 48...
Effects of Partial Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Respiratory Distress
Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(11):1430-1439.   Published online November 15, 2000
Purpose : To evaluate gas exchange, hemodynamics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress. Methods : In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaO2 at FiO2 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized...
A Study of Surface Physical Properties of New Surfactant Using Synthetic Peptides of Surfactant Protein-B
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Sang-Chul Lee, Kil Lyong Kim, Kyung-Soo Hahm
Clin Exp Pediatr. 2000;43(8):1059-1067.   Published online August 15, 2000
Purpose : To produce a new generation of artificial pulmonary surfactant(PS), surfactant protein (SP)-B from human PSwas isolated, and the amino acid sequences of these proteins were studied. Artificial peptides of human SP-B were synthesized. New artificial PS preparations which were composed of phospholopids and two artificial synthetic SP-B peptides were made, and the surface physical properties of these new PS preparations were tested. Methods...
Comparison of Preventive Effect of RDS and Neonatal Morbidity between Antenatal Dexamethasone versus Ambroxol Administration
Eun Jeong, Kim, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 2000;43(1):13-22.   Published online January 15, 2000
Purpose : Antenatal dexamethasone administration is associated with a significant lowering respiratory distress syndrome(RDS) incidence, but can increase neonatal infection. Ambroxol has been accepted as an alternative treatment to dexamethasone and is of at least equal efficacy but without adverse reaction. The aim of this study was to evaluate the effectiveness of ambroxol versus dexamethasone in RDS incidence and neonatal...
Inhalation of Bronchodilator Aerosol by Metered-dose Inhaler and Spacer in Neonatal Respiratory Distress Syndrome
Hyeon-Soo Lee
Clin Exp Pediatr. 1999;42(12):1668-1675.   Published online December 15, 1999
Purpose : To examine the clinical effects of two bronchodilator agents, salbutamol and ipratropium bromide, administered by metered-dose inhaler(MDIS) to preterm infants with respiratory distress syndrome(RDS) during mechanical ventilation. Methods : This study included 8 ventilated preterm infants with RDS, at a postnatal age of 1 week. The effects of single doses of salbutamol(2puffs, 200mcg) and ipratropium bromide(2 puffs, 36mcg) and...
Correlation between Changes of Intrapulmonary Right to Left Shunt and Improvements in Oxygenation after Exogenous Surfactant Administration in Preterm Respiratory Distress Syndrome
Sei Woo Chung
Clin Exp Pediatr. 1999;42(10):1373-1380.   Published online October 15, 1999
Purpose : This study was aimed to investigate the relationship between changes in intrapulmonary right to left shunt(QSP/QT) and improvements in oxygenation during the 2-hr study period after Surfactant-TA(S-TA) administration. Methods : Umbilical arterial blood gases and corresponding respiratory indexes of 27 preterm neonates with respiratory distress syndrome were studied. The neonates were separated into group A(n=20) and group B(n=7) according...
Antenatal Thyrotropin-Releasing Hormone to Prevent Respiratory Distress Syndrome in Preterm
Ai-Rhan Kim, Sung-Jong Park, Hye-Sun Yoon, Ki-Soo Kim, Hye-Sung Won, In-Sik Lee, Ahm Kim, Soo-Young Pi
Clin Exp Pediatr. 1999;42(7):911-920.   Published online July 15, 1999
Purpose : The purpose of this study was to assess the efficacy of antenatal thyrotropin-releasing hormone(TRH) given to mothers at risk for preterm delivery and assess various neonatal outcomes in infants born to these mothers. Methods : Sixty-one mothers(TRH＋Dexamethasone(D):30, D:31) with preterm labor at 26-34 weeks of gestational age were randomized into a study group which received 400μg of TRH at...
Doppler Echocardiographic Assessment of the Changes in Pulmonary Arterial Pressure in Preterm Infants with Respiratory Distress Syndrome
Sejung Sohn, Eun Ae Park
Clin Exp Pediatr. 1999;42(6):790-799.   Published online June 15, 1999
Purpose : The ratio of time to peak velocity(AT) and right ventricular ejection time(ET) as measured from the pulmonary artery Doppler waveform showed a close inverse correlation with pulmonary arterial pressure. The purpose of this study was to see the pattern of change in pulmonary arterial pressure assessed by AT/ET in preterm infants with respiratory distress syndrome (RDS). Methods : The...
Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment
Hyeon-Soo Lee, Myung-Seo Kang
Clin Exp Pediatr. 1999;42(5):644-649.   Published online May 15, 1999
Purpose : The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life. Methods : This study included 8 preterm infants with respiratory distress...
Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
Clin Exp Pediatr. 1999;42(4):472-483.   Published online April 15, 1999
Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(9):1188-1197.   Published online September 15, 1998
Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one...
Erratum
Perinatal Factors Influencing Clinical Response to Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome
June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(8):1023-1032.   Published online August 15, 1998
Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical...
Original Article
Preparation and in vitro Physical Activities of Crude Natural Surfactant and Artificial Pulmonary Surfactant Containing Synthetic Peptide and Phospholipid Mixtures
Joo Hyun Kang, Song Yub Shin, Cheol-Young Maeng, Kil Lyong Kim, Chong-Woo Bae, Kyung-Soo Hahm
Clin Exp Pediatr. 1998;41(4):472-480.   Published online April 15, 1998
Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B were synthesized and restored the surface tension lowering activities when appropriately recombined with phospholipid. Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation...
Effects of Early Dexamethasone Therapy in Neonatal Respiratory Distress Syndrome
Hyeon-Soo Lee
Clin Exp Pediatr. 1998;41(1):19-25.   Published online January 15, 1998
Purpose : To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome. Methods : 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg...
Influences of the Intrapulmonary R→L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
Yoon Hyung Park, Sei Woo Chung, Seung Baik Han, Young Se Kwon, Ji Youn Kim, Woo Sik Cheong, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 1997;40(11):1508-1519.   Published online November 15, 1997
Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit...
A Study of Relation between Stable Microbubble Rating and Surfactant Derivatives(SurfactenⓇ : Phospholipid :, ExosurfⓇ : Dipalmitoyl-Phosphatidyl Choline) Concentration in Vitro
Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim, Min Hee Kim
Clin Exp Pediatr. 1997;40(7):939-944.   Published online July 15, 1997
Purpose : With the recent advent of surfactant replacement therapy, there is an increasing need for a rapid and reliable test to predict respiratory distress syndrome (RDS) immediately before or at birth. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. The stable microbubble rating test (SMR-test) developed by pattle et al. is rapid and simple test...
Case Report
A Case of Severe Pulmonary Complication and ARDS Secondary to Peanut Aspiration in 15 Month Old Male
Sung Keun Moon, Chang Keun Kim, Churl Young Chung
Clin Exp Pediatr. 1997;40(3):423-428.   Published online March 15, 1997
Foreign body aspiration(especially peanut) is the leading cause of accidental death in children under 1 year of age and most cases of serious aspiration occur between the age of 1 and 3. We report a case of severe pulmonary complication and adult respiratory distress syndrome(ARDS) secondary to peanut aspiration in 15 month old male in spite of all removal(9 pieces) by ventilating bronchoscope. Chest...
An Autopsy Case of Tracheal Agenesis Type 2
Hyun Joo Lee, Eun Ae Park, Seung Joo Lee, Mi Jeong Kim, Soon Hee Seong
Clin Exp Pediatr. 1996;39(12):1759-1762.   Published online December 15, 1996
Tracheal agenesis is the rare and uniformly lethal anomaly that presents with severe respiratory distress and aphonia after birth. In this anomaly, the trachea is usually absent and air is reaching the bronchi through a communication with the esophagus. The diagnosis should be suspected in a nowborn infant with respiratory distress whose intubation is difficult. We report an autopy case of tracheal...
An Autopsy Case of Double Aortic Arch
Ji Sook Kim, Yong Myung Jo, Kyung Hee Ko, Eun Ryoung Kim, Je Grun Chi
Clin Exp Pediatr. 1996;39(5):727-731.   Published online May 15, 1996
Double aortic arch is the most common type of symptomatic vascularring. In most patients, the symptoms are manifested at birth or in early infancy. Double aortic arch usually has more severe symptoms than other types of complete vascular rings. We experienced one case of complete duplicated double aortic arch with left descending aorta and left patent ductus arteriosus. A one-day-old female neonate was transferred...
Original Article
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
Sequential Changes of Chest Radiographic Finding after Exogenous Surfactant Replacement Therapy in Neonates with RDS
Hyeok Choi, Chong-Woo Bae, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1995;38(2):151-158.   Published online February 15, 1995
Purpose : The chest radiograph is useful and reliable in assessing the severity and progres-sion of neonatal respiratory distress syndrome. To evaluate the effect of exogenous surfactant r eplacement therapy, we performed sequential observation of chest radiogratphic findings in ne-onates with respiratory distress syndrome. Methods : Two groups of infant with RDS in mechanical ventilation therapy were studied. S-urfactant(S-Tx) group(n=36) was...
Clinical Study of Transient Tachypnea of the Newborn
Young Soo Kweon, Soo Jin Jung, Chang hee Han, Hae Woon Jang, Ki Ho Kim
Clin Exp Pediatr. 1995;38(1):10-19.   Published online January 15, 1995
Transient tachypnea of the newborn(TTN) is a benign self-limited disease characterized by early onset and rapid recovery of tachypnea although it may occasionally have a more prolonged and protracted course. A retrospective clinical study was mad on 29 neonates with TTN admitted to NICU of Pohang St. Mary's Hospital from January 1992 to June 1993. The results were as follows: 1) TTN(36.2%) was...
Diagnostic Value of Stable Microbubble Rating Test and Shake Test for the Early Detection of Respiratory Distress Syndrome in Prematurity
Sung Eun Lee, Sang Lak Lee, Chin Moo Kang
Clin Exp Pediatr. 1994;37(11):1500-1507.   Published online November 15, 1994
Respiratory distress syndrome (RDS) of newborn is a disease revealed high morbidity and mortality rate, especially in premature infant. To evaluate the predictive value of Stable Microbubble Rating (SMR) and Shake test on RDS in premature infant, the anthors carried out the gastric aspirates Shake test and SMR test at birth, 3 and 6 hours after birth respectively on 124 premature...
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